TY - JOUR AU - Yegya-Raman, Nikhil AU - Shah, Mihir M. AU - Grandhi, Miral S. AU - Poplin, Elizabeth AU - August, David A. AU - Kennedy, Timothy J. AU - Malhotra, Usha AU - Spencer, Kristen R. AU - Carpizo, Darren R. AU - Jabbour, Salma K. PY - 2018 TI - Adjuvant therapeutic strategies for resectable pancreatic adenocarcinoma JF - Annals of Pancreatic Cancer; Vol 1 (August 2018): Annals of Pancreatic Cancer Y2 - 2018 KW - N2 - Of all patients diagnosed with pancreatic adenocarcinoma, only 15–20% present with resectable disease. Despite curative-intent resection, the prognosis remains poor with the majority of patients recurring, prompting the need for adjuvant therapy. Historical data support the use of adjuvant 5-fluorouracil (5-FU) or gemcitabine, but recent data suggest either gemcitabine plus capecitabine or modified FOLFIRINOX can improve overall survival when compared to gemcitabine alone. The use of adjuvant chemoradiation therapy remains controversial, primarily due to limitations in study design and mixed results of historical trials. The ongoing Radiation Therapy Oncology Group (RTOG)-0848 trial hopes to further define the role of adjuvant chemoradiation therapy. Intraoperative radiation therapy (IORT) and adjuvant immunotherapy represent additional possibilities to improve outcomes, but evidence supporting their use is limited. This article reviews adjuvant therapeutic strategies for resectable pancreatic adenocarcinoma, including chemotherapy, chemoradiation therapy, IORT and immunotherapy. UR - https://apc.amegroups.org/article/view/4410