TY - JOUR AU - Buicko, Jessica L. AU - Finnerty, Brendan M. AU - Zhang, Tiantian AU - Kim, Bu Jung AU - Fahey III, Thomas J. AU - Du, Yi-Chieh Nancy PY - 2019 TI - Insights into the biology and treatment strategies of pancreatic neuroendocrine tumors JF - Annals of Pancreatic Cancer; Vol 2 (June 2019): Annals of Pancreatic Cancer Y2 - 2019 KW - N2 - Pancreatic neuroendocrine tumors (PNETs) are the second most common primary pancreatic neoplasms after pancreatic ductal adenocarcinoma. PNETs present with widely various clinical manifestation and unfavorable survival rate. The recent advances in next generation sequencing have significantly increased our understanding of the molecular landscape of PNETs and help guide the development of targeted therapies. This review intends to outline a holistic picture of the tumors by discussing current understanding of clinical presentations, up-to-date treatment strategies, novel mouse models, and molecular biology of PNETs. Furthermore, we will provide insight into the future development of more effective targeted therapies that are necessary to manage PNETs. UR - https://apc.amegroups.org/article/view/4896